| In vitro drug diffusion testing
of the transfer rate across a membrane is a technology used for
the study of skin transfer kinetics and to establish batch-to-batch
uniformity of topical preparations. The procedure employs a diffusion
cell that separates a donor compartment from a receptor compartment
with a specified membrane. Complete turn-key systems for diffusion
cell testing are available from Hanson Research.
The MicroettePlus system provides automatic sampling from diffusion
cells and collection into HPLC vials for sample analysis. The
system automates sampling protocols from groups of six diffusion
cells for extensive un-attended tests, and handles surfactants,
saline and hydroalcoholic receptor solutions.
The new MicroettePlus incorporates Hanson AutoPlus technology,
including precision 6-channel syringe pump, Teflon valves and
sample tubing, Easy-Icon programming with graphical display, convenient
pop-up menus and help screens, up to 25 test protocols, 21CFR11
compliant firmware, "smart switch" for system communications,
automatic media replace at time of sampling, programmable cell
dilutions, jacketed media replace beaker, and supply kit. A choice
of Hanson precision vertical diffusion cells, 6-cell drive system
with stainless stand, MultiFill collector with interchangeable
HPLC vial racks, validation printer, and heater circulating bath
round out the complete system package. |
 The
vertical diffusion cell, first popularized by Dr. Thomas Franz,
has been applied to a number of skin permeation studies, including
topical and transdermal drug delivery formulations, as well
as opthalmics, cosmetics, skin care products and pesticides.
The vertical diffusion cell system is an ideal tool for quality
control of topical preparations (see FDA guideline SUPAC SS).
The Hanson vertical diffusion cell is newly redesigned for accuracy
and ease of use, based on over fifteen years of rigorous industry,
university and regulatory application.
 Precision
glass cell assemblies include receptor chamber, donor chamber
with easy-use clamp, dosage wafer (300 mg "infinite dose"
or other volumes available), sampling and media replace ports,
outside jacket for temperature control, and Helix stirrer. Cells
may be manually sampled, or automated with the MicroettePlus.
Cells are designed to be "occluded" (sealing the donor
from air) to minimize any back-diffusion from automated sampling.
Cells include individual serial numbers, and are available in
three convenient sizes. |
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